Agmatine as an Analgesic

When you have aches and pains all over, analgesics are typically the first thing that you probably turn to. Analgesics are extremely various in how they work but agmatine is one amino acid that particularly stands out from the rest of the crowd. What is it that makes agmatine so interesting? Agmatine has the ability to not only work as a weak analgesics, but it can even potientiate other analgesics. In other words, agmatine can not only alleviate pain but can also increase the healing potential of other analgesics.analgesic

What exactly is agmatine?

Scientifically speaking, agmatine is an amine that is formed by decarboxylation of L-arginine by the enzyme arginine decarboxylase (ADC) and hydrolyzed by the enxyme agmatinase to putrescine. This may be a mouthful of scientific words to most people, but it also shows exactly how agmatine does what it does. Observations by scientists suggested that agmantine may have functions of a novel neurotransmitter/neuromodulator.

What does agmatine do?

The physiological role of agmatine in normal brain function is still unknown, but what is known about agmatine is that when administered intrathecally agmatine reduces the neuronal injury produced by excitotoxins, global/focal ischemia, spinal cord injury, and hypoxic ischemic injury.

But that’s know all agmatine is known to do, as agmatine has been found to reduce chemically and electrically induced convulsive seizures, and agmatine has be proposed as an adjunct in the management of several chronic pain syndromes, and has been effective in facilitating the action of morphine while profoundly reducing the development of tolerance. This means that not only can agmatine help with pain, but it helps a person’s body from developing a tolerance to other analgesics.

In the end, if you find yourself having a hard time choosing an analgesic, agmatine is a prime choice. Even if you decide on another analgesic, agmatine can be used to boost the power of whatever else you take, showing that it’s always a good decision to have some agmatine in your house.




David Johnson is a freelancer with an avid interest in supplements that help relax, enhance mood, and provide cognitive enhancement. Most days he can be found researching innovative ways to bring his readers sounder sleep, better moods, and more.