Synergistic Effects of DMAE and Alpha-GPC

In the supplement world today we are constantly introduced to new compounds and research that provide evidence that suggests certain supplements are best when paired with others. In fact, some supplements require the aid of another synergistic ingredient to have any significant effect at all. One such synergistic relationship that is being talked about in many circles today is the combination of DMAE and alpha-GPC. The synergistic effects of this pair have been linked to an improved state of mood, improved focus, attention, mental energy, and mental clarity. With that said let’s take a look at both supplements individually and break down just what it is that makes this combination so great.

DMAE Benefitssynergy of nootropics

Abbreviated DMAE, dimethylethanolamine is a transparent, pale-yellow liquid that has many health benefits as a standalone supplement. A study conducted in 2003 by German scientists looked at the efficacy of DMAE in increasing vigilance and alertness in addition to having a positive influence on mood. The study concluded that supplementation of DMAE does result in a psychological state of better feeling of well being  this conclusion is supported by both a subject mood analysis and the monitoring of electrical patterns in the subjects brain activity. Known as a “mind-health” compound this supplement acts an ant-aging device in that it reduces the buildup of what is known as the “age pigment”, a substance that is involved with cognitive impairment and decline with age. As if that wasn’t enough, DMAE has the ability to act as an anti-oxidant in the body protecting neurons and cells from certain types of oxidation.

Alpha GPC Benefits

L-alpha-glycerophosphocholin, or alpha-GPC for short, is a cholinergic compound that is an easy to absorb source of dietary choline. Alpha-GPC is known for its ability to increase physical output and cognition. Although alpha-GPC is found naturally in the brain and in milk, the compound is available as a nootropic dietary supplement. Research identifying the physical benefits that come with supplementation of alpha-GPC is published in the Journal of the International Society of Sports Nutrition; the results conclude that a dose 45 minutes prior to a training session resulted in an increase of post-exercise serum GH and peak bench press power. As for an increase in cognition, alpha-GPC works as a cognitive stimulatory agent through increasing the activity of protein Kinase C in neurons. You can buy alpha-GPC here.

DMAE and Alpha GPC Dosage

With the facts before you it is not hard to draw your own conclusions as to how these two supplements can work together to create unique health and wellness benefits. The compounds have a very beneficial synergistic relationship in that they are able to enhance and prolong the benefits that come with supplementation. It is important to note that these compounds are classified as nootropics, meaning dosage and supplementation is an important piece of the puzzle. I would recommend a dose of 300-600mg for alpha-GPC and DMAE dosage should start around 200mg while working up to but not exceeding 700mg. As always one should be attentive to his/her own personal response to any supplement and adhere to the dosage information provided on your products packaging/label.



David Johnson is a freelancer with an avid interest in supplements that help relax, enhance mood, and provide cognitive enhancement. Most days he can be found researching innovative ways to bring his readers sounder sleep, better moods, and more.